Serveur d'exploration sur la COVID chez les séniors

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Cerebrovascular Complications of COVID-19.

Identifieur interne : 000827 ( Main/Exploration ); précédent : 000826; suivant : 000828

Cerebrovascular Complications of COVID-19.

Auteurs : Jeffrey M. Katz [États-Unis] ; Richard B. Libman [États-Unis] ; Jason J. Wang ; Pina Sanelli [États-Unis] ; Christopher G. Filippi [États-Unis] ; Michele Gribko [États-Unis] ; Steven V. Pacia [États-Unis] ; Ruben I. Kuzniecky [États-Unis] ; Souhel Najjar [États-Unis] ; Salman Azhar [États-Unis]

Source :

RBID : pubmed:32757751

Descripteurs français

English descriptors

Abstract

BACKGROUND AND PURPOSE

Coronavirus disease 2019 (COVID-19) evolved quickly into a global pandemic with myriad systemic complications, including stroke. We report the largest case series to date of cerebrovascular complications of COVID-19 and compare with stroke patients without infection.

METHODS

Retrospective case series of COVID-19 patients with imaging-confirmed stroke, treated at 11 hospitals in New York, between March 14 and April 26, 2020. Demographic, clinical, laboratory, imaging, and outcome data were collected, and cases were compared with date-matched controls without COVID-19 from 1 year prior.

RESULTS

Eighty-six COVID-19-positive stroke cases were identified (mean age, 67.4 years; 44.2% women). Ischemic stroke (83.7%) and nonfocal neurological presentations (67.4%) predominated, commonly involving multivascular distributions (45.8%) with associated hemorrhage (20.8%). Compared with controls (n=499), COVID-19 was associated with in-hospital stroke onset (47.7% versus 5.0%;

CONCLUSIONS

COVID-19 is an independent risk factor for stroke in hospitalized patients and mortality, and stroke presentations are frequently atypical.


DOI: 10.1161/STROKEAHA.120.031265
PubMed: 32757751
PubMed Central: PMC7467046


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<term>Aged, 80 and over (MeSH)</term>
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<term>Brain Ischemia (therapy)</term>
<term>Cerebral Angiography (MeSH)</term>
<term>Cerebrovascular Disorders (etiology)</term>
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<term>Cerebrovascular Disorders (therapy)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Ethnic Groups (MeSH)</term>
<term>Female (MeSH)</term>
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<term>Intracranial Hemorrhages (complications)</term>
<term>Intracranial Hemorrhages (mortality)</term>
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<term>Adulte d'âge moyen (MeSH)</term>
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<term>Infections à coronavirus (mortalité)</term>
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<term>Pneumopathie virale (complications)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (thérapie)</term>
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<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
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<term>Cerebrovascular Disorders</term>
<term>Coronavirus Infections</term>
<term>Intracranial Hemorrhages</term>
<term>Pneumonia, Viral</term>
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<term>Angiopathies intracrâniennes</term>
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<term>Coronavirus Infections</term>
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<term>Stroke</term>
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<term>Accident vasculaire cérébral</term>
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<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Hémorragies intracrâniennes</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>État de New York</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr">
<term>Accident vasculaire cérébral</term>
<term>Angiopathies intracrâniennes</term>
<term>Encéphalopathie ischémique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cerebral Angiography</term>
<term>Ethnic Groups</term>
<term>Female</term>
<term>Hospital Mortality</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuroimaging</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Angiographie cérébrale</term>
<term>Ethnies</term>
<term>Facteurs de risque</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mortalité hospitalière</term>
<term>Mâle</term>
<term>Neuroimagerie</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>
<b>BACKGROUND AND PURPOSE</b>
</p>
<p>Coronavirus disease 2019 (COVID-19) evolved quickly into a global pandemic with myriad systemic complications, including stroke. We report the largest case series to date of cerebrovascular complications of COVID-19 and compare with stroke patients without infection.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Retrospective case series of COVID-19 patients with imaging-confirmed stroke, treated at 11 hospitals in New York, between March 14 and April 26, 2020. Demographic, clinical, laboratory, imaging, and outcome data were collected, and cases were compared with date-matched controls without COVID-19 from 1 year prior.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Eighty-six COVID-19-positive stroke cases were identified (mean age, 67.4 years; 44.2% women). Ischemic stroke (83.7%) and nonfocal neurological presentations (67.4%) predominated, commonly involving multivascular distributions (45.8%) with associated hemorrhage (20.8%). Compared with controls (n=499), COVID-19 was associated with in-hospital stroke onset (47.7% versus 5.0%; </p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>COVID-19 is an independent risk factor for stroke in hospitalized patients and mortality, and stroke presentations are frequently atypical.</p>
</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">32757751</PMID>
<DateCompleted>
<Year>2020</Year>
<Month>09</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised>
<Year>2020</Year>
<Month>09</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1524-4628</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>51</Volume>
<Issue>9</Issue>
<PubDate>
<Year>2020</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Stroke</Title>
<ISOAbbreviation>Stroke</ISOAbbreviation>
</Journal>
<ArticleTitle>Cerebrovascular Complications of COVID-19.</ArticleTitle>
<Pagination>
<MedlinePgn>e227-e231</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/STROKEAHA.120.031265</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND AND PURPOSE">Coronavirus disease 2019 (COVID-19) evolved quickly into a global pandemic with myriad systemic complications, including stroke. We report the largest case series to date of cerebrovascular complications of COVID-19 and compare with stroke patients without infection.</AbstractText>
<AbstractText Label="METHODS">Retrospective case series of COVID-19 patients with imaging-confirmed stroke, treated at 11 hospitals in New York, between March 14 and April 26, 2020. Demographic, clinical, laboratory, imaging, and outcome data were collected, and cases were compared with date-matched controls without COVID-19 from 1 year prior.</AbstractText>
<AbstractText Label="RESULTS">Eighty-six COVID-19-positive stroke cases were identified (mean age, 67.4 years; 44.2% women). Ischemic stroke (83.7%) and nonfocal neurological presentations (67.4%) predominated, commonly involving multivascular distributions (45.8%) with associated hemorrhage (20.8%). Compared with controls (n=499), COVID-19 was associated with in-hospital stroke onset (47.7% versus 5.0%;
<i>P</i>
<0.001), mortality (29.1% versus 9.0%;
<i>P</i>
<0.001), and Black/multiracial race (58.1% versus 36.9%;
<i>P</i>
=0.001). COVID-19 was the strongest independent risk factor for in-hospital stroke (odds ratio, 20.9 [95% CI, 10.4-42.2];
<i>P</i>
<0.001), whereas COVID-19, older age, and intracranial hemorrhage independently predicted mortality.</AbstractText>
<AbstractText Label="CONCLUSIONS">COVID-19 is an independent risk factor for stroke in hospitalized patients and mortality, and stroke presentations are frequently atypical.</AbstractText>
</Abstract>
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<Author ValidYN="Y">
<LastName>Katz</LastName>
<ForeName>Jeffrey M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo>
<Affiliation>Departments of Neurology (J.M.K., R.B.L., M.G., S.V.P., R.I.K., S.N., S.A.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Radiology (J.M.K, P.S., C.G.F), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Libman</LastName>
<ForeName>Richard B</ForeName>
<Initials>RB</Initials>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Wang</LastName>
<ForeName>Jason J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo>
<Affiliation>Feinstein Institute for Medical Research at Northwell Health, Manhasset, NY (J.J.W.).</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Sanelli</LastName>
<ForeName>Pina</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Radiology (J.M.K, P.S., C.G.F), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
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<Initials>CG</Initials>
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<ForeName>Michele</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Departments of Neurology (J.M.K., R.B.L., M.G., S.V.P., R.I.K., S.N., S.A.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Pacia</LastName>
<ForeName>Steven V</ForeName>
<Initials>SV</Initials>
<AffiliationInfo>
<Affiliation>Departments of Neurology (J.M.K., R.B.L., M.G., S.V.P., R.I.K., S.N., S.A.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kuzniecky</LastName>
<ForeName>Ruben I</ForeName>
<Initials>RI</Initials>
<AffiliationInfo>
<Affiliation>Departments of Neurology (J.M.K., R.B.L., M.G., S.V.P., R.I.K., S.N., S.A.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Najjar</LastName>
<ForeName>Souhel</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Departments of Neurology (J.M.K., R.B.L., M.G., S.V.P., R.I.K., S.N., S.A.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Azhar</LastName>
<ForeName>Salman</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Departments of Neurology (J.M.K., R.B.L., M.G., S.V.P., R.I.K., S.N., S.A.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2020</Year>
<Month>08</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>United States</Country>
<MedlineTA>Stroke</MedlineTA>
<NlmUniqueID>0235266</NlmUniqueID>
<ISSNLinking>0039-2499</ISSNLinking>
</MedlineJournalInfo>
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<SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D002545" MajorTopicYN="N">Brain Ischemia</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
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</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002533" MajorTopicYN="N">Cerebral Angiography</DescriptorName>
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<DescriptorName UI="D002561" MajorTopicYN="N">Cerebrovascular Disorders</DescriptorName>
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<Keyword MajorTopicYN="Y">demography</Keyword>
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